Botox vs Xeomin: Which Should You Choose?

At PREEMA, we believe that choosing an injectable isn’t just a clinical decision—it’s a personal one. Whether you're exploring wrinkle treatments for the first time or looking to refine your current regimen, understanding the difference between Botox® and Xeomin® can help you make a confident, empowered choice.

Our goal? To guide you with clarity and care—so your results feel elegant, natural, and completely you.

Botox vs Xeomin at a Glance

Which Option Is Best for You?

Some patients choose Xeomin for its purity and reduced risk of immune resistance. Others prefer the broader treatment range and familiarity of Botox.

At PREEMA, we don’t believe in shortcuts. We assess your movement patterns, goals, lifestyle, and even previous injectable history to craft a solution as unique as your face.

“While both products achieve similar goals, their formulation is where the distinction lies,” explains Dr. Andrew Gassman, Medical Director at PREEMA. “Xeomin’s clean profile can be beneficial for certain patients, especially those who have developed resistance to other neuromodulators.”

How Does Botox and Xeomin Work for Wrinkles? 

Both Botox and Xeomin work by temporarily blocking nerve signals to targeted muscles, causing them to relax. This softens lines caused by facial expressions, resulting in smoother, more youthful-looking skin. The treatment process for both is similar:

• A consultation to discuss your goals and determine the best treatment areas
• Quick, minimally invasive injections using a fine needle
• A short recovery period with minimal downtime
• Gradual results appearing over 5-14 days post-treatment

“A wrinkle relaxer should never erase your personality,” says Amanda Hernandez, PA-C. “At PREEMA, we tailor every injectable to enhance your unique beauty—not freeze it. It’s about softening lines while preserving movement and elegance.”

Understanding the Differences between Botox and Xeomin 

While Botox and Xeomin share many similarities, there are some notable differences:

• Formulation: Xeomin contains only the botulinum toxin A, while Botox includes additional proteins. This "naked" formulation of Xeomin may reduce the risk of developing antibodies that could make the treatment less effective over time.
• Storage: Due to its purer form, Xeomin doesn't require refrigeration, which can extend its shelf life.
• Onset of action: Some patients report that Xeomin may take slightly longer to show full effects compared to Botox.
• Versatility: Botox is approved for use in more areas of the face, while Xeomin is primarily used for frown lines.
• Brand recognition: Botox has been on the market longer and has stronger brand recognition among patients. 

How Effective are Botox and Xeomin Wrinkle Treatments? 

Both Botox and Xeomin offer clinically proven results. At PREEMA, we help you choose the option that aligns with your lifestyle, aesthetic goals, and long-term wellness. Patients typically see noticeable improvements in the appearance of wrinkles within two weeks of treatment. The effects generally last for 3-4 months, though some patients report longer-lasting results, especially with repeated treatments over time.

It's important to note that the effectiveness of these treatments can vary based on factors such as the individual's muscle strength, metabolism, and the skill of the injector. Choosing a qualified aesthetic injector in San Antonio, like the experienced team at PREEMA, is crucial for achieving optimal results.

Are there Potential Side Effects with Botox and Xeomin Injections? 

While both treatments are generally safe when administered by a qualified professional, there are potential side effects to be aware of:

• Temporary bruising or swelling at the injection site
• Mild headache
• Drooping eyelid (in rare cases, affecting less than 1% of patients)
• Dry eyes or mouth
• Difficulty swallowing (rare)

How to Select Which Treatment is Right for You?

Choosing between Botox and Xeomin depends on several factors. Consider the following when making your decision:

• Your specific problem areas and desired outcomes
• Any history of allergies or sensitivities to injectable treatments
• Your preference for a more established brand (Botox) or a newer, "purer" formulation (Xeomin)
• The recommendation of your skincare professional based on your individual needs

“There’s no one-size-fits-all in aesthetics,” Amanda shares. “Some clients love the versatility of Botox, while others respond beautifully to Xeomin’s pure formulation. That’s why we always begin with a personalized consultation.”

What to Expect After a Wrinkle Injection Treatment 

After receiving either Botox or Xeomin injections, you can expect:

• Minimal downtime - most patients can resume normal activities immediately
• Gradual improvement in the appearance of wrinkles over 5-14 days
• Full results visible within two weeks
• Effects lasting approximately 3-4 months
• The need for follow-up treatments to maintain results

To maximize your results and minimize potential side effects, follow your provider's aftercare instructions carefully. This may include avoiding strenuous exercise, saunas, or hot tubs for 24-48 hours post-treatment.

FAQ: Botox vs Xeomin – Which Is Right for You?

What is the main difference between Botox and Xeomin?
The key difference lies in their formulation. Botox contains additional accessory proteins, while Xeomin is a purified or “naked” version that includes only the active botulinum toxin type A. This makes Xeomin less likely to trigger antibody resistance and ideal for patients sensitive to additives.

Which lasts longer: Botox or Xeomin?
Both typically last 3 to 4 months. Some patients report slightly longer effects with repeated treatments, but duration is generally similar. Factors like metabolism, muscle strength, and injection technique can impact longevity.

Is Xeomin better for first-time patients?
Xeomin’s purer formulation may be preferable for patients concerned about building resistance or those seeking a cleaner injectable. However, Botox is more widely recognized and approved for more treatment areas. A consultation at PREEMA helps determine the best fit for your goals.

Can Botox and Xeomin be used interchangeably?
In many cases, yes. Both target facial muscles to reduce wrinkles, but your provider may recommend one over the other based on your treatment history, preferences, or desired outcomes.

Are there side effects to be aware of?
Both treatments are considered safe when administered by a trained provider. Possible side effects include mild bruising, swelling, headache, or temporary eyelid droop. These effects are rare and usually resolve quickly.

How soon will I see results from Botox or Xeomin?
Results typically begin to appear within 3 to 5 days and reach full effect by 10 to 14 days. Some clients notice Xeomin takes slightly longer to activate, though results are comparably effective once visible.

Interested in Exploring Wrinkle Injection Treatments in San Antonio? Schedule a Consultation to Rejuvenate Your Skin

Ready to smooth expression lines with confidence and grace?

Schedule a personalized consultation with Amanda Hernandez, PA-C at PREEMA in San Antonio and explore your wrinkle relaxer options in a luxurious, medically trusted setting.

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